Haworth, Brian T. Sutch, Rebecca M. Romero Objectives To evaluate faculty-led discussion meetings (with about eight students) conducted face-to-face (in-class) or by synchronous, real-time videoconference (online), in a biopharmaceutics course taught in a facilitated problem-based learning (PBL) format. Methods Three methods were used to compare in-class versus online discussion sessions for two semesters. The first method involved three parameters that measured the quality of interactions between faculty (facilitator) and student (Fc–St), participation of students in the discussions (Par), and student–student interactions (St–St). The second method assessed student’s perceptions of the discussions with surveys. The third method mapped the interactions (a sociogram) between faculty (facilitator) and students in a discussion. Results There were significantly lower scores for Par and St–St (P
Physiological purpose and you can pharmacology away from curcumin
Publication ChapterAsma El-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca Meters. Romero, Ian S Haworth Curcumin ‘s the major element of the brand new reddish dye from turmeric, an Indian spice that’s taken from the newest rhizome of warm bush Curcuma longa, and this belongs to the Zingiberaceae family members. Within chapter, we talk about the pharmacological situations away from curcumin and you may explore the brand new unit bases of these items. I next feedback the brand new demonstrated and you will potential clinical spends of curcumin. Curcumin is known typically because a curative broker, but the method from action is actually detailed. The latest pharmacological effects of curcumin appear to be caused by an excellent synergism of sites regarding poor biochemical connections with multiple biological objectives in the interrelated signaling pathways. This type of objectives become nutrients particularly cyclooxygenase, lipoxygenase and protein kinases, and you will transcription circumstances such as NF-?B, STAT and you can Nrf2. Modulation of these particles affects downstream affectors which make brand new antiinflammatory, antioxidant, chemopreventive, anticancer, and you may antimicrobial affairs regarding curcumin. Such consequences was basically checked-out inside health-related examples out-of curcumin to possess soreness and you may inflammatory disorder, cancer, Alzheimer state, cardiovascular disorder, and you may all forms of diabetes. The new examples have used variable dosages away from curcuminwith additional wavelengths and you can years, to the general end one to higher amounts of curcumin on level of grams are required to see therapeutic consequences. Find out more
Curcumin: Synthesis, Emerging Character during the Pain Management and Fitness Ramifications
Publication Section Types of plant-derived pharmaceuticals that have get to be the attention off proceeded and rapid browse and you will development notice features, thus far, started slightly scarce. Immediately after a long period, the final twenty years was basically described as a great 100-bend upsurge in exactly how many scientific blogs typed a year one try out of advantages to your usage of curcumin inside biomedicine. Read more
Structure, synthesis and you can biological things away from curcumin prodrugs
Publication ChapterAsma El-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca M. Romero, Ian S Haworth Curcumin has some prospective pharmacological effects and could possess therapeutic programs in lots of disease claims, just like the discussed in more detail in the last section. But not, the possibility logical effectiveness out-of curcumin is bound from the the physicochemical services out of bad liquids solubility and you will imbalance, and therefore bring about reduced bioavailability. Prodrugs from curcumin offer an effective way to improve of your biopharmaceutical and you may pharmacokinetic characteristics, and may also create exploitation of pharmacological effects of curcumin. Inside section, we basic remark the physicochemical and you may pharmacokinetics away from curcumin. We next describe the style of curcumin prodrugs with improved h2o solubility and you will increased agents balance that can easily be translated back into free curcumin abreast of bioactivation when you look at träffa Venezuelanska kvinnor the vivo. I high light recent success in this region, which have a focus on the structure, synthesis and you will research regarding prodrugs based on promoieties as well as proteins, essential fatty acids, nucleic acids, dicarboxylic acids, and polymeric information eg hyaluronic acid and you can polyethylene glycol. Which chapter gets the cause for optimisation of physicochemical and you will biopharmaceutical attributes and the biological facts away from curcumin prodrugs, towards purpose playing with of those curcumin types inside the clinical programs. Find out more